AN ESTIMATE IS WORTH ABOUT A THOUSAND EXPERIMENTS: USING ORDER-OF-MAGNITUDE ESTIMATES TO IDENTIFY CELLULAR ENGINEERING TARGETS

An estimate is worth about a thousand experiments: using order-of-magnitude estimates to identify cellular engineering targets

Abstract Biotechnological processes use microbes to convert abundant molecules, such as glucose, into high-value products, such as pharmaceuticals, commodity and fine chemicals, and energy.However, from the outset of the development of a new bioprocess, it is difficult to determine the feasibility, expected yields, and targets for engineering.In th

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Society for Immunotherapy of Cancer (SITC) consensus definitions for resistance to combinations of immune checkpoint inhibitors

Immunotherapy is the standard of care for several cancers and the field continues to advance at a rapid pace, with novel combinations leading to indications in an increasing number of disease settings.Durable responses and long-term survival with immunotherapy have been demonstrated in some patients, though lack of initial benefit and recurrence af

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